Closed-weight biology models
15
Models
12 organisations
0%
Open weights
0 open, 15 closed
0
Frontier
By Epoch's flag
100B
Largest traceable
xTrimoPGLM -100B
2017–2024
Span
4 with a traceable size
Organisation
Records
15| Model | Organisation | Released | Parameters | Weights |
|---|---|---|---|---|
| AlphaProteo | Google DeepMind | 2024-09 | — | Closed |
| ESM3 (98B) | EvolutionaryScale | 2024-06 | 99B | Closed |
| AlphaMissense | Google DeepMind | 2023-09 | 93M * | Closed |
| GGNN | Westlake University | 2023-08 | — | Closed |
| xTrimoPGLM -100B | Tsinghua University | 2023-07 | 100B | Closed |
| LEP-AD | King Abdullah University of Science and Technology (KAUST) | 2023-03 | 3B | Closed |
| CaLM | University of Oxford | 2022-12 | 86M * | Closed |
| TranceptEve | University of Oxford | 2022-12 | — | Closed |
| OmegaPLM | Massachusetts Institute of Technology (MIT) | 2022-07 | 670M | Closed |
| Eve | Harvard Medical School | 2021-10 | 15M * | Closed |
| Fold2Seq | IBM | 2021-06 | 12M * | Closed |
| AlphaFold | DeepMind | 2020-01 | 16M * | Closed |
| RaptorX-Contact | Toyota Technological Institute at Chicago | 2019-05 | — | Closed |
| NetSurfP-2.0 | Technical University of Denmark | 2018-09 | — | Closed |
| DeepLoc | Technical University of Denmark | 2017-07 | — | Closed |
An asterisk marks a parameter figure the source does not consider traceable to the people who built the model. That judgement is the source’s and it has false negatives: Kimi K3 is marked speculative at 2.8T while Moonshot’s own model card states the figure. Why that distinction carries the whole exhibit.
Counts are of models Epoch AI records as notable, not of every model released. The most recent month is always incomplete, because a model enters the dataset when it is reviewed rather than when it ships.
Epoch AI, 'Data on AI Models'. Published online at epoch.ai. Retrieved from 'https://epoch.ai/data/ai-models-documentation' Used under CC BY 4.0.