The AI Museum
AI Analytics1,072 recordsRecounted 23 September 2026

Closed-weight biology models from United States of America

7

Models

6 organisations

0%

Open weights

0 open, 7 closed

0

Frontier

By Epoch's flag

99B

Largest traceable

ESM3 (98B)

2019–2024

Span

2 with a traceable size

Records

7
Closed-weight biology models from United States of America, newest first. Each row links to the source Epoch AI records for it.
ModelOrganisationReleasedParametersWeights
AlphaProteoGoogle DeepMind2024-09Closed
ESM3 (98B)EvolutionaryScale2024-0699BClosed
AlphaMissenseGoogle DeepMind2023-0993M *Closed
OmegaPLMMassachusetts Institute of Technology (MIT)2022-07670MClosed
EveHarvard Medical School2021-1015M *Closed
Fold2SeqIBM2021-0612M *Closed
RaptorX-ContactToyota Technological Institute at Chicago2019-05Closed

An asterisk marks a parameter figure the source does not consider traceable to the people who built the model. That judgement is the source’s and it has false negatives: Kimi K3 is marked speculative at 2.8T while Moonshot’s own model card states the figure. Why that distinction carries the whole exhibit.

Counts are of models Epoch AI records as notable, not of every model released. The most recent month is always incomplete, because a model enters the dataset when it is reviewed rather than when it ships.

Epoch AI, 'Data on AI Models'. Published online at epoch.ai. Retrieved from 'https://epoch.ai/data/ai-models-documentation' Used under CC BY 4.0.

How this museum is made